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Caption | Histological analysis of the endocrine pancreas in Vhltm1Lss/Vhltm1Lss Tg(Pdx1-cre)89.1Dam/0 mice. A. Immunofluorescent staining of representative pancreas in Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre; panel a) and Vhltm1Lss/Vhltm1Lss Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;Vhl f/f) mice (panels b and c) to demonstrate abnormally shaped and hyperplastic islets (red) in mutant mice at 16-18 months of age. Images are taken at 100x. B. Immunofluorescent images of representative pancreas in controls (Pdx1-Cre; panels a-c) and mutants (panels d-i) to demonstrate hypervascularity within islets of mutant mice. Blood vessels are visualized via FITC-lectin injection (green; panels b, e, and h) while pancreatic islets are identified using an anti-insulin antibody (red; panels c, f, and i). Images are taken at 200x. | ||||
Copyright | This image is from Shen HC, PLoS ONE 2009;4(4):e4897, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148174 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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