Phenotype Image Detail

Image

Caption

Histological analysis of the endocrine pancreas in Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0 mice. A. Immunofluorescent staining of representative pancreas in Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre; panel a) and Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;Vhl f/f) mice (panels b and c) to demonstrate abnormally shaped and hyperplastic islets (red) in mutant mice at 16-18 months of age. Images are taken at 100x. B. Immunofluorescent images of representative pancreas in controls (Pdx1-Cre; panels a-c) and mutants (panels d-i) to demonstrate hypervascularity within islets of mutant mice. Blood vessels are visualized via FITC-lectin injection (green; panels b, e, and h) while pancreatic islets are identified using an anti-insulin antibody (red; panels c, f, and i). Images are taken at 200x.

Copyright

This image is from Shen HC, PLoS ONE 2009;4(4):e4897, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148174

Associated Alleles

Symbol	Name
Vhl^tm1Lss	von Hippel-Lindau tumor suppressor; targeted mutation 1, Laura S Schmidt

Associated Genotypes

Allelic Composition	Genetic Background
Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0	involves: 129X1/SvJ * C57BL/6 * CBA