Phenotype Image Detail

Image

Caption

Bone development in Ptpn2^tm1Mtr/Ptpn2^tm1Mtr (Ptpn2-/-; BALB/c) mice. Representative longitudinal sections of tibiae from (a) 14 day-old Ptpn2^tm1Mtr/Ptpn2^tm1Mtr (Ptpn2-/-; BALB/c), Ptpn2^tm1Mtr/Ptpn2^tm1Mtr (Ptpn2-/-; C57BL/6) and Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig (Ptpn2^ex2-/ex2-) mice, or (b) 21 day-old Ptpn2-/- (BALB/c) and Ptpn2^ex2-/ex2- mice and their corresponding littermate wild-type controls stained with the von Kossa technique (mineralized bone stained black). In a) safranin O staining [only shown for 14 day-old Ptpn2+/+ (BALB/c) and Ptpn2-/- (BALB/c)] highlights the delayed cartilage (in orange) destruction; scale bar = 100 micron.

Copyright

This image is from Wiede F, PLoS One 2012;7(5):e36703, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:186843

Associated Alleles

Symbol	Name
Ptpn2^tm1Mtr	protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1, Michel L Tremblay
Ptpn2^tm2.1Ttig	protein tyrosine phosphatase, non-receptor type 2; targeted mutation 2.1, Tony Tiganis

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn2^tm1Mtr/Ptpn2^tm1Mtr	C.129S4-Ptpn2^tm1Mtr
Ptpn2^tm1Mtr/Ptpn2^tm1Mtr	B6.129S4(C)-Ptpn2^tm1Mtr
Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig	B6.Cg-Ptpn2^tm2.1Ttig