Phenotype Image Detail

Image

Caption

Gross phenotype of Tgm3^tm1Sjo/Tgm3^tm1Sjo (-/-) mice. Southern blot analysis of tail biopsies from mice born of heterozygous interbreeding showed that homozygous mutants were born at the expected Mendelian ratios (A). The pelage hair of homozygous animals at 4 weeks of age showed a distinctive wavy pattern (B and C). This became less obvious as the mice matured (D). While gross hair abnormalities disappear with time, irregularities in the vibrissae, which are evident perinatally (E, mutant; F, control at P5) persist throughout life. Expression of Tgm3 is observed in pelage hair in the medulla and in the inner root sheath (G).

Copyright

This image is from John S, PLoS One 2012;7(4):e34252, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187109

Associated Alleles

Symbol	Name
Tgm3^tm1Sjo	transglutaminase 3, E polypeptide; targeted mutation 1, Susan John

Associated Genotypes

Allelic Composition	Genetic Background
Tgm3^tm1Sjo/Tgm3^tm1Sjo	involves: 129P2/OlaHsd * C57BL/6