Phenotype Image Detail

Image

Caption

The myometrium is disrupted in aged nulliparous Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit (Antxr2-/-) reproductive tracts. (A) Immunofluorescence for alpha-SMA (red) demonstrated well-defined circular and longitudinal myometrial cell layers that were beginning to disassociate in 6.5 week homozygous mutant tissue. Space between myometrial cell bundles is indicated by asterisks in the homozygous tissue. (B) Alpha-SMA (red) staining of three-month-old tissue demonstrated that the disassociation between the myometrial layers had progressed in homozygous mutant uterine and cervical tissue. In the uterus, the dispersal was such that the remaining muscle bundles could not be captured together in the same photographic frame. Arrows indicate where two images were placed together in order to demonstrate the distance between the longitudinal and circular myometiral cell layers in the mutant uterus. DAPI (blue color) is used for nuclear staining. Scale bars, 150 um.

Copyright

This image is from Reeves CV, PLoS One 2012;7(4):e34862, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187210

Associated Alleles

Symbol	Name
Antxr2^tm1.1Jkit	anthrax toxin receptor 2; targeted mutation 1.1, Jan K Kitajewski

Associated Genotypes

Allelic Composition	Genetic Background
Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit	involves: 129 * C57BL/6