Phenotype Image Detail

Image

Caption

Deafness and abnormal cochlea in rda/rda and Elmod1^rda-2J/Elmod1^rda-2J mice. A. ABR thresholds (dB SPL) of rda/rda and Elmod1^rda-2J/Elmod1^rda-2J (rda^2J/rda^2J) mutant mice and non-mutant controls tested at 33-48 days of age. ABRs for 8, 16, and 32 kHz stimulus frequencies were not detected in any of the rda/rda (N=9) and Elmod1^rda-2J/Elmod1^rda-2J (N=8) mutant mice tested, even with the maximum stimulus presentation of 100 dB SPL. Heterozygous and wild-type mice were combined as controls because their ABR thresholds did not significanlty differ from one another. Error bars represent standard deviations of the threshold means. B, C. Cross sections through the basal turn of the cochlea from heterozygous control (+/rda) mouse (B) and a littermate rda/rda mutant mouse (C) examined at 4 months of age. Note the complete degeneration of the organ of Corti (oc) and decreased density of spiral ganglion cells (sgc) in the homozygous mutant cochlea. Scale bars represent 100 um. Cochlear cross sections of Elmod1^rda-2J/Elmod1^rda-2J mutant mice (not shown) exhibited this same pathology.

Copyright

This image is from Johnson KR, PLoS One 2012;7(4):e36074, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187273

Associated Alleles

Symbol	Name
Elmod1^rda-2J	ELMO/CED-12 domain containing 1; roundabout 2 Jackson
rda	roundabout

Associated Genotypes

Allelic Composition	Genetic Background
rda/rda	C57BL/6J-rda/JKjn
Elmod1^rda-2J/Elmod1^rda-2J	B6.Cg-Elmod1^rda-2J/JKjn
rda/rda^+	C57BL/6J-rda/JKjn