Phenotype Image Detail

Image

Caption

Recently weaned mice were injected 3 consecutive days with tamoxifen and the small intestines from control (Con) and Slc39a4^tm2Gka/Slc39a4^tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 (Zip4-intestine knockout; Zip4 intest KO) mice (5 mice per group) were harvested on the indicated days after initiation of the knockout. (A) Sections of small intestine were stained with hematoxylin-eosin. Sections from control day 0 and day 6 intestine are shown (2 left side panels), whereas sections from Zip4-intestine knockout days 2-4 and day 6 intestine are shown (4 right side panels). (B) A blow-up view of the Slc39a4^tm2Gka/Slc39a4^tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 d6. Black arrowheads demarcate examples of cubodial epithelial cells and RBCs in the lamina propria.

Copyright

This image is from Geiser J, PLoS Genet 2012 Jun;8(6):e1002766, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187178

Associated Alleles

Symbol	Name
Slc39a4^tm2Gka	solute carrier family 39 (zinc transporter), member 4; targeted mutation 2, Glen K Andrews
Tg(Vil1-cre/ERT2)23Syr	transgene insertion 23, Sylvie Robine

Associated Genotypes

Allelic Composition	Genetic Background
Slc39a4^tm2Gka/Slc39a4^tm2Gka Tg(Vil1-cre/ERT2)23Syr/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2