Phenotype Image Detail

Image

Caption

Middle ear and inner ear histology in Chd7^Ome/Chd7⁺ mice. (A-B) Effusion (blue arrows) and tympanic membrane retraction (blue asterisk) can be seen in the mutant mice. (C) In the mutant mice, the head of the stapes is moved toward the anterior crus (white arrow); the obturator foramen is smaller because of inward growth of the footplate and anterior crus (white arrowheads); the footplate is thinner and partially fused with surrounding bones (red asterisk). (D-E) In mutant mice, effusion was evident with a small amount of inflammatory cells (yellow asterisk); the tympanic membrane (yellow arrow), middle ear epithelia (upper right yellow arrowhead) and round window ridge (central yellow arrowhead) were thickened. (F-G) Enlarged images from corresponding control and mutant mice (white rectangles in D and E) to show the inner ear morphology; SV, stria vascularis; RM, Reissner's membrane; TM, tectorial membrane; IHC, inner hair cell; OHC, outer hair cell; SPG, spiral ganglion neuron. (H-I) Eustachian tube openings in the control and mutant mice. MEC, middle ear cavity. (J-K) Dilated periostea (green asterisk) and thickened epithelia (white arrows) were observed in the mutant mice. (L-M) Inflammatory cells in the MEC of mutant mice. (N-O) Eustachian tube openings in six-month-old mutant mice and littermate control mice. Scale bars: D, E, F, G, I = 100 um; H, J, K, L, M = 50 um.

Copyright

This image is from Tian C, PLoS One 2012;7(4):e34944, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187200

Associated Alleles

Symbol	Name
Chd7^Ome	chromodomain helicase DNA binding protein 7; Otitis media and eye defects

Associated Genotypes

Allelic Composition	Genetic Background
Chd7^Ome/Chd7^+	involves: BALB/cByJ * C57BL/6J