Phenotype Image Detail

Image

Caption

Representative sections of the middle ear and Eustachian tube mucosae of wild-type (WT) and Chd7^Ome/Chd7⁺ littermates. Few goblet cells could be found in the middle ear (A) and Eustachian tube mucosae (C) of wild-type littermate mice. By contrast, goblet cells were present at high density among other cells in the epithelium of the middle ear cavity (B) and the duct of the Eustachian tube (D) of mutant mice (typical goblet cells are indicated by arrows). Goblet cells have a distinctly polarized morphology in which the nucleus stains black in color at the cell base, and the mucus stains a deep rose color in the middle and apical portions of the cell. Scale bars = 50 um.

Copyright

This image is from Tian C, PLoS One 2012;7(4):e34944, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187200

Associated Alleles

Symbol	Name
Chd7^Ome	chromodomain helicase DNA binding protein 7; Otitis media and eye defects

Associated Genotypes

Allelic Composition	Genetic Background
Chd7^Ome/Chd7^+	involves: BALB/cByJ * C57BL/6J