Phenotype Image Detail

Image

Caption

Scanning electron micrographs of middle ear cavities of Chd7^Ome/Chd7⁺ mice and littermate control mice. (A, B) Lateral views of Eustachian tube ostium epithelia in 1-month-old wild-type (A) and mutant (B) mice show increased goblet cells in mutant mice while ciliary morphology is indistinguishable from that in wild-type mice. Red asterisk identifies one of many goblet cells. (C, D) Rarefied cilia (green arrowhead) and scattered goblet cells (red asterisk) were observed in the mucociliary epithelia at the Eustachian tube ostia of 12-month-old mutant mice (D), while the cilia in age-matched wild-type mice (C) appeared normal. Scale bars = 15 um.

Copyright

This image is from Tian C, PLoS One 2012;7(4):e34944, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187200

Associated Alleles

Symbol	Name
Chd7^Ome	chromodomain helicase DNA binding protein 7; Otitis media and eye defects

Associated Genotypes

Allelic Composition	Genetic Background
Chd7^Ome/Chd7^+	involves: BALB/cByJ * C57BL/6J