Phenotype Image Detail

Image

Caption

Aberrant morphology of Paneth and goblet cells of mice hemizygous or homozygous for Yipf6^M1Btlr (Klein-Zschocher). Electron microscopy of Paneth (I, J, M, and N) and goblet (K, L, O, and P) cells. Electron microscopy revealed diminutive and disorganized granules in Paneth cells (I, J, M, and N). In goblet cells, mucin granules were slightly smaller in size and more variable in electron density than in wild-type mice (K, L, O, and P).

Copyright

This image is from Brandl K, Proc Natl Acad Sci U S A 2012 Jul 31;109(31):12650-5. Copyright 2012 National Academy of Sciences, U.S.A. J:187584

Associated Alleles

Symbol	Name
Yipf6^M1Btlr	Yip1 domain family, member 6; mutation 1, Bruce Beutler

Associated Genotypes

Allelic Composition	Genetic Background
Yipf6^M1Btlr/Y	C57BL/6J-Yipf6^M1Btlr/Mmucd
Yipf6^M1Btlr/Yipf6^M1Btlr	C57BL/6J-Yipf6^M1Btlr/Mmucd