Phenotype Image Detail

Image

Caption

Fibrosis in the submuscosal layer of 10-week-old Ahr^tm1Yfk/Ahr^tm1Yfk (AhR-/-) bladders. Masson's trichrome stain of heterozygous (A and C) and Ahr^tm1Yfk/Ahr^tm1Yfk (homozygous) (B and D) bladders, demonstrating fibrosis of the homozygous mutant bladder with an increased amount of collagen (blue) and enlarged blood vessels. (Scale bars in A and B, 500 um; C and D, 20 um.)

Copyright

This image is from Butler R, Proc Natl Acad Sci U S A 2012 Jan 9;():. Copyright 2012 National Academy of Sciences, U.S.A. J:179919

Associated Alleles

Symbol	Name
Ahr^tm1Yfk	aryl-hydrocarbon receptor; targeted mutation 1, Yoshiaki Fujii-Kuriyama

Associated Genotypes

Allelic Composition	Genetic Background
Ahr^tm1Yfk/Ahr^tm1Yfk	involves: 129S/SvEv * C57BL/6J