Phenotype Image Detail

Image

Caption

Numerous round particles were visible in the luminal side of the urothelium of a 10-week-old Ahr^tm1Yfk/Ahr^tm1Yfk mouse (B and D), whereas no particles exist in the heterozygous control (A and C). Cytoplasm and particles are stained pink with eosin and nuclei are stained purple with Mayer's hematoxylin. These structures stain positive (brown-black color) for Grocott's methenamine silver stain, which can be a marker for uric acid (F), whereas the control bladder remains negative (E). After a 1-hour treatment with uricase and hydrogen peroxide, these granules are not present in the epithelium of the 4-month-old Ahr^tm1Yfk/Ahr^tm1Yfk bladder (H). The granules are still present in the control treatment of only hydrogen peroxide in PBS (G). (Scale bars in A, B, E, and F, 20 um; C, D, G, and H, 10 um.)

Copyright

This image is from Butler R, Proc Natl Acad Sci U S A 2012 Jan 9;():. Copyright 2012 National Academy of Sciences, U.S.A. J:179919

Associated Alleles

Symbol	Name
Ahr^tm1Yfk	aryl-hydrocarbon receptor; targeted mutation 1, Yoshiaki Fujii-Kuriyama

Associated Genotypes

Allelic Composition	Genetic Background
Ahr^tm1Yfk/Ahr^tm1Yfk	involves: 129S/SvEv * C57BL/6J