Phenotype Image Detail

Image

Caption

Skeletogenesis is severely impaired in Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-cre;Apc^15lox/15lox) mice. (A-E) Greatly impaired skeletal development and growth arrest of mutant embryos. Gross appearance (A-C) and Alcian blue and Alizarin red staining (D-E) of skeletal preparations of mutant embryos and control littermates at indicated developmental stages. Conditional Apc mutants showed lack of mandible outgrowth (arrowheads), poor limb development (black arrows), and an open thoracic and abdominal cavity (red arrows). Scale bars: 1 mm.

Copyright

This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225

Associated Alleles

Symbol	Name
Apc^tm1Rsmi	APC, WNT signaling pathway regulator; targeted mutation 1, Ron Smits
Tg(Col2a1-cre)1Rsjo	transgene insertion 1, Randall S Johnson

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0	involves: 129P2/OlaHsd * FVB/N