Image |
|
||||||
Caption | No chondrogenic and osteogenic differentiation in the developing humerus due to lack of functional Apc. (A-B) Immunostaining for beta-catenin combined with Alcian blue (AB) staining (A), combined with von Kossa-Toluidine blue staining (B), and (C-J) gene expression analysis by in situ hybridization with indicated probes for (C-F) chondrocytes, (G-I) osteoblasts and (J) osteoclasts on consecutive transversal sections of the developing humerus of a Apctm1Rsmi/Apctm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-Cre;Apc15lox/15lox) embryo and control littermate at E16.5. Beta-catenin-positive spindle-shaped cells organize in clusters and failed to express chondrogenic and osteogenic markers (arrowheads). Beta-catenin-negative cells at the periphery of these clusters expressed early chondrogenic markers only (arrows), probably due to lack of Cre-mediated loss of functional Apc. Scale bars: 100 um. | ||||||
Copyright | This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225 | ||||||
Associated Alleles |
|
||||||
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/17/2024 MGI 6.24 |
![]() |
|