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Caption | Conditional Apc inactivation enhances osteoblast formation and mineral deposition in the developing proximal rib. (A-L) Immunostaining for beta-catenin combined with Alcian blue (AB) staining (A,E), combined von Kossa-Toluidine blue staining (F), hematoxylin/eosin staining (G), gene expression analysis by in situ hybridization with indicated probes for chondrogenic (B,C), osteogenic (D, H-J) and osteoclastogenic differentiation (K) on consecutive transversal sections of the developing proximal rib of a Apctm1Rsmi/Apctm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-Cre;Apc15lox/15lox) embryo and control littermate at E14.5 (A-D) and E16.5 (E-K). The double-headed arrows in G indicate the thickness of the rib. (L) Tartrate-resistant acid phosphatase (TRAP) staining of the developing proximal rib of a mutant embryo at E16.5. The boxed region in L is magnified in L' showing multinucleated osteoclasts (arrowheads) staining positive for TRAP. Scale bars: 100 um in A-L; 50 um in L'. | ||||||
Copyright | This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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