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Caption | Dedifferentiation in the nasal septum of Apctm1Rsmi/Apctm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-cre;Apc15lox/15lox) embryos at E16.5. (A, E) Hematoxylin/eosin staining, (B, F, H) immunostaining for beta-catenin combined with Alcian blue (AB) staining, and (C-D, G, I) gene expression analysis by in situ hybridization with indicated probes for chondrogenic differentiation on consecutive transversal sections of hte developing nasal septum of a mutant embryo and control littermate at E16.5. (F', G', H', I') High magnification pictures of the boxed regions in F, G, H, and I, respectively. Mesenchymal-like beta-catenin-positive cells (arrow in F, H) were present between crumbled cartilage islands. Within these cartilage islands, although displaying chondrocytic morphology and an Alcian blue stained matrix, most of the beta-catenin-positive cells did not express Sox9 (arrowheads in G') or Col2a1 (arrows in I'). Scale bars: 100 um in A, E, F, H; 5 um in F', H'. | ||||||
Copyright | This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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