Phenotype Image Detail

Image

Caption

BTG3 (ANA) deficiency enhances bone formation after BMP (bone morphogenetic protein) implantation in muscles in Btg3^tm1Tya/Btg3^tm1Tya (KO) mice. A: left panel, shape and size of cholesterol-bearing pullulan cross-linked by poly ethylene glycol (CHP-PEG); right panel, CHP-PEG containing BMP2 was implanted into the quadriceps of the right side (orange arrow) and CHP-PEG-containing vehicle was implanted into the left side (pink arrow). B, x-ray images of newly formed bone after implantation of BMP in CHP-PEG in quadriceps of wild-type (top) and mutant mice (bottom). Orange arrows indicate radiopaque signal of ectopically formed bone induced by BMP. Contralateral side (CHP-PEG with vehicle alone) of either wild-type or mutant mice did not indicate any bone formation. C, three-dimensional bone volume of the ectopically formed bone (ossicle) after implantation in both wild-type and mutant mice. *, p<0.05.

Copyright

This image is from Miyai K, J Biol Chem 2009 Apr 17;284(16):10593-600 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:149251

Associated Alleles

Symbol	Name
Btg3^tm1Tya	BTG anti-proliferation factor 3; targeted mutation 1, Tadashi Yamamoto

Associated Genotypes

Allelic Composition	Genetic Background
Btg3^tm1Tya/Btg3^tm1Tya	involves: 129P2/OlaHsd * C57BL/6J