Phenotype Image Detail

Image

Caption

Melanoma growth was suppressed in Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu (KO) mice in both mixed and C57BL/6 backgrounds. (A, a) Tumorigenesis of melanoma cells was reduced in mutant knockout (KO) mice in the mixed background. B16-F10 cells (10⁷ mouse melanoma cells) were injected s.c. into Gpr68^tm1Yaxu/Gpr68^tm1Yaxu (FL) and Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu (KO) mice in the mixed background. Mice were sacrificed at 9-14 days post-injection. (b) Representative pictures of the tumors developed in FL and KO mice in the mixed background. (B) Summary of tumor volumes (a) and weights (b) in mice with the C57BL/6 background (n = 10 in wild-type and n = 12 in KO). Tumorigenesis of melanoma cells was reduced in KO mice.

Copyright

This image is from Li H, PLoS One 2009;4(5):e5705, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:149315

Associated Alleles

Symbol	Name
Gpr68^tm1.1Yaxu	G protein-coupled receptor 68; targeted mutation 1.1, Yan Xu
Gpr68^tm1Yaxu	G protein-coupled receptor 68; targeted mutation 1, Yan Xu

Associated Genotypes

Allelic Composition	Genetic Background
Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu	involves: 129S4/SvJae * C57BL/6 * FVB/N
Gpr68^tm1Yaxu/Gpr68^tm1Yaxu	involves: C57BL/6