Phenotype Image Detail

Image

Caption

Fgfr2^tm3Ewj/Fgfr2⁺ mice have cutis gyrata, acanthosis, skull synostosis, and other abnormalities. (A-D) Note skin furrows and hyperplasia in the mutant mice at P0 (A and B). With age, the skin phenotype becomes more obvious at P3 (C and D). (E-H) Surface reconstructions of HRCT images show midfacial hypoplasia of the mutant mice at P0. Note premature fusion of the coronal suture (E-H; black arrows), zygomaxillary suture (E-H; white arrows), and squamosal suture (E-H; red arrow) (I and J) Alizarian red S and Alcian blue staining of the chest show abnormal bony fusion of sternum in mutant at P0. (K and L) Gross observations reveal protruding and enlarged umbilical stump in mutant (arrow). A, C, E, G, I, and K are from littermate controls. B, D, F, H, J, and L show the corresponding organs and tissues in mutant mice.

Copyright

This image is from Wang Y, J Clin Invest 2012 Jun 1;122(6):2153-64 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190491

Associated Alleles

Symbol	Name
Fgfr2^tm3Ewj	fibroblast growth factor receptor 2; targeted mutation 3, Ethylin Wang Jabs

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm3Ewj/Fgfr2^+	B6.129-Fgfr2^tm3Ewj