Phenotype Image Detail

Image

Caption

Micro-CT surface reconstructions of the skulls of Fgfr2^tm3Ewj/Fgfr2⁺ (Y394C/+) mice at P8. (A and B) Superior views with nose upward. (C and D) Lateral views with nose to the left. (E and F) Inferior views with mandible removed, including close ups of the palate, nose upward (left). Distances between the length of the nasal bones, between the face and lateral vault, between the face and the petrous temporal bone, and between palate and the anterior cranial base are longer in the littermate controls relative to the mutants (A, C, E; red lines). In contrast, nasal width, sphenoid width, posterior cranial base length, dimensions of the petrous temporal, and posterior vault length are relatively shorter in the littermate controls (A, C, E; blue lines). Reported differences are, after scaling for overall differences in size, significant by bootstrap confidence intervals (alpha = 0.10). In mutants, coronal suture closure (B and D; black arrows) and the zygomaxillary suture closure are apparent (B and D; white arrows). The frontomaxillary (B and D; red arrows) and frontonasal suture (B; yellow arrow) are completely fused in mutants, while the premaxillary-maxillary suture (F; blue arrow) and intermaxillary suture (F; striped arrow) are more fused in mutants than controls.

Copyright

This image is from Wang Y, J Clin Invest 2012 Jun 1;122(6):2153-64 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190491

Associated Alleles

Symbol	Name
Fgfr2^tm3Ewj	fibroblast growth factor receptor 2; targeted mutation 3, Ethylin Wang Jabs

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm3Ewj/Fgfr2^+	B6.129-Fgfr2^tm3Ewj