Phenotype Image Detail

Image

Caption

(A) Left: Sarcoma from the hind left limb of an 89-week-old male Wif1^tm1Dmth/Wif1^tm1Dmth mouse, arising adjacent to periosteum, and infiltrating skeletal muscle. The adjacent cortical bone (black arrow) and skeletal muscle fiber surrounded by sarcoma cells (red arrow) are indicated. Right: Osteosarcoma from the lumbar spine of a 56-week-old female homozygous mutant mouse, showing a malignant osteoid (yellow arrow). Scale bars: 100 um. (B) Radiation-induced osteosarcoma model schematic. (C) Typical imaging appearance of osteosarcomas. Top: 18F-PET scan demonstrating intense avidity of osteoblastic tumors from the same mouse. Bottom: Histology of mouse radiation-induced osteosarcoma. Original magnification, x20.

Copyright

This image is from Kansara M, J Clin Invest 2009 Apr;119(4):837-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149607

Associated Alleles

Symbol	Name
Wif1^tm1Dmth	Wnt inhibitory factor 1; targeted mutation 1, David M Thomas

Associated Genotypes

Allelic Composition	Genetic Background
Wif1^tm1Dmth/Wif1^tm1Dmth	involves: 129 * C57BL/6