Phenotype Image Detail

Image

Caption

Developmental defects of Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺ (128-7) embryos. Lateral (a and b) and frontal (c and d) views of age matched wild-type (WT) and mutant embryos at E10.5. Mutant embryos fail to complete embryonic turning; head and branchial arches are dysmorphic, and the pericardium is swollen and contains blood (b). WT embryos (c) exhibit rightward looping morphogenesis during heart development. The direction of heart looping morphogenesis is randomized in mutants. Heart looping morphogenesis is reversed in the mutant embryo (d). Embryos in (c and d) are labeled for Nkx2-5 expression to enhance visualization of the heart tube. At E10.5 the yolk sac of WT embryos (e) has formed a well-developed vasculature (arrows) compared with mutant embryos (f), which fail to form mature blood vessels in the yolk sac (arrows).

Copyright

This image is from Hagarman JA, Genesis 2009 Jun;47(6):392-403, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:149893

Associated Alleles

Symbol	Name
Ednrb^s-24Pub	endothelin receptor type B; Pu239 citrate alpha ray induced 24Pub
m128-7Tpo	mutation 128-7, Timothy P O'Brien

Associated Genotypes

Allelic Composition	Genetic Background
Ednrb^s-24Pub/Ednrb^+ m128-7Tpo/m128-7Tpo^+	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ