Phenotype Image Detail

Image

Caption

Cell metabolism and cardiac function of Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe Myl2^tm1(cre)Krc/Myl2⁺ (CKO) mice. A, BODIPY 493/503 staining for lipid droplets in isolated wild-type (WT) and mutant (CKO) cardiomyocytes from 4-month-old mice. Insets show magnified droplets. Wild-type cells show small lipid droplets uniformly distributed in cells, while mutants show heterogenous lipid drops. Scale bar, 20 um; inset scale bar, 2 um. B, periodic acid-Schiff staining (scale bar, 50 um); C, TEM (transmission electron microscopy) (scale bar, 2 um) for lipofuscin in WT and mutant (CKO) hearts. Mutant heart has more lipofusin granules than wild-type heart.

Copyright

This image is from Zhao T, J Biol Chem 2012 Jul 6;287(28):23615-25 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:188865

Associated Alleles

Symbol	Name
Mfn2^tm1.1Mzhe	mitofusin 2; targeted mutation 1.1, Ming Zheng
Myl2^tm1(cre)Krc	myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien

Associated Genotypes

Allelic Composition	Genetic Background
Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe Myl2^tm1(cre)Krc/Myl2^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J