Phenotype Image Detail

Image

Caption

Histology and immunofluorescence of P21 kidney sections. (A and E) wild-type (+/+) (A) and Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf (-/-) (E) H&E-stained renal cortex. Tubular vacuolation is evident in the mutant section (black arrows). Normal plasma membrane accentuation of H⁺-ATPases in wild-type collecting duct cells is observed with E1 (also present intracellularly in generic H⁺-ATPases) and B1 subunit stains (B and C) (white arrows). This is absent in mutant kidney (F and G). Normal pendrin staining (D) is not seen in mutant section (H). (Scale bars: 20 um.)

Copyright

This image is from Norgett EE, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13775-80. Copyright 2012 National Academy of Sciences, U.S.A. J:188593

Associated Alleles

Symbol	Name
Atp6v0a4^tm1.1Fekf	ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1.1, Fiona E Karet Frankl

Associated Genotypes

Allelic Composition	Genetic Background
Atp6v0a4^tm1.1Fekf/Atp6v0a4^tm1.1Fekf	involves: C57BL/6