Phenotype Image Detail

Image

Caption

(E) Comparison of the coat color phenotypes of three Atp7a mutants. Mice carrying the brown allele (Atp7a^Mo-3Btlr/Atp7a⁺, Atp7a^Mo-3Btlr/Y, or Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr), have brown fur and do not exhibit variegated pigmentation as is seen in Atp7a^Mo-2Btlr/Atp7a⁺ (Tigrou female), and Atp7a^Mo-Btlr/Atp7a⁺ (Tigrou-like female) females. Atp7a^Mo-2Btlr/Y (Tigrou male) mice lack pigmentation except at their extremities.

Copyright

This image is from Siggs OM, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13733-8. Copyright 2012 National Academy of Sciences, U.S.A. J:188598

Associated Alleles

Symbol	Name
Atp7a^Mo-2Btlr	ATPase, copper transporting, alpha polypeptide; mottled 2 Bruce Beutler
Atp7a^Mo-3Btlr	ATPase, copper transporting, alpha polypeptide; mottled 3 Bruce Beutler
Atp7a^Mo-Btlr	ATPase, copper transporting, alpha polypeptide; mottled Bruce Beutler

Associated Genotypes

Allelic Composition	Genetic Background
Atp7a^Mo-Btlr/Atp7a^+	C57BL/6J-Atp7a^Mo-Btlr
Atp7a^Mo-2Btlr/Atp7a^+	C57BL/6J-Atp7a^Mo-2Btlr
Atp7a^Mo-2Btlr/Y	C57BL/6J-Atp7a^Mo-2Btlr
Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr	C57BL/6J-Atp7a^Mo-3Btlr
Atp7a^Mo-3Btlr/Y	C57BL/6J-Atp7a^Mo-3Btlr
Atp7a^Mo-3Btlr/Atp7a^+	C57BL/6J-Atp7a^Mo-3Btlr