Phenotype Image Detail

Image

Caption

Colon tumors induced by azoxymethane/dextrate sulfate sodium salt (AOM/DSS) treatment. Neu3^tm1Yamk/Neu3^tm1Yamk (KO) or wild-type (wild) mice were subjected to a single AOM injection followed by DSS administration in the drinking water. Colons were dissected 20 weeks after AOM injection and fixed with formalin. A. Macroscopic photograph of dissected colons. Tumors developed at the distal ends of colons are indicated by arrowheads for easy recognition. B. Micrographs of the colon adenocarcinoma. Representative examples of adenocarcinomas developed in the mutant (left) or in the wild-type (right) mouse. Sections from paraffin-embedded tumors were stained with hematoxylin and eosin by standard techniques. Bars, 0.1 mm.

Copyright

This image is from Yamaguchi K, PLoS One 2012;7(7):e41132, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189604

Associated Alleles

Symbol	Name
Neu3^tm1Yamk	neuraminidase 3; targeted mutation 1, Kazunori Yamaguchi

Associated Genotypes

Allelic Composition	Genetic Background
Neu3^tm1Yamk/Neu3^tm1Yamk	B6.129-Neu3^tm1Yamk