Phenotype Image Detail

Image

Caption

Placental and heart abnormalities in Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg (Dlc1^gt/gt) embryos. (i) Immunofluorescent staining of the placenta of 10.5 days post coitum (dpc) heterozygous (Dlc1^wt/gt) and homozygous mutant embryos with PECAM (CD31) antibody. Twelve micrometer thick frozen paraformaldehyde fixed placental sections were incubated with anti-PECAM-1 antibody and then with FITC conjugated secondary antibody. (ii) The yellow arrow indicates a continuous network of blood vessel in the placental labyrinth haematoxylin and eosin stained sections of placental labyrinth of 10.5 dpc heterozygous and homozygous mutant embryos. Black asterisks indicate fetal erythrocytes and the yellow asterisk indicates maternal red blood cells. (iii) Transverse section of the X-gal stained heart of 10.5 dpc heterozygous and homozygous mutant embryos. The yellow asterisk indicates normal thick trabeculated ventricular wall; the red asterisk thin smooth atria wall; and the green asterisk with fetal erythrocytes.

Copyright

This image is from Sabbir MG, BMC Biol 2010;8():17, an open-access article, licensee BioMed Central Ltd. J:189950

Associated Alleles

Symbol	Name
Dlc1^Gt(XE082)Byg	deleted in liver cancer 1; gene trap XE082, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Dlc1^Gt(XE082)Byg/Dlc1^Gt(XE082)Byg	involves: 129P2/OlaHsd * C57BL/6