Phenotype Image Detail

Image

Caption

Neural tissues from newborn Pikfyve^{Gt(AT0926)Wtsi}/Pikfyve^{Gt(AT0926)Wtsi} (Pikfyve^{Beta-geo/Beta-geo}) mice exhibit modest degeneration. (A) Coronal sections of the cerebral cortex of neonatal wild-type (WT) and homozygous mutant mice stained with H&E showing modest vacuolation in the caudal region of the subventricular neuroepithelium (arrow). (B) The dorsal root ganglion (DRG) was more affected and contained large vacuoles (arrow). (C) Vacuolation (arrow) occurred in hippocampal neurons from P0 homozygous mutant mice cultured for 13 days (DIV).

Copyright

This image is from Zolov SN, Proc Natl Acad Sci U S A 2012 Oct 23;109(43):17472-7. Copyright 2012 National Academy of Sciences, U.S.A. J:190368

Associated Alleles

Symbol	Name
Pikfyve^Gt(AT0926)Wtsi	phosphoinositide kinase, FYVE type zinc finger containing; gene trap AT0926, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Pikfyve^Gt(AT0926)Wtsi/Pikfyve^Gt(AT0926)Wtsi	involves: 129P2/OlaHsd * C57BL/6