Phenotype Image Detail

Image

Caption

Profound defects in the lungs of Pikfyve^{Gt(AT0926)Wtsi}/Pikfyve^{Gt(AT0926)Wtsi} (Pikfyve^{Beta-geo/Beta-geo}) mutants. (A) Lungs from wild-type (WT) mice have thin septae (arrowhead) between the alveolae. The homozygous mutants have decreased airspace in the lung, thick septae between the alveolae (arrowhead), and vascular congestion of the capillary beds surrounding the alveolae (arrow). Note the increased ratio of cellularity to alveolar area in the homozygous mouse lung. (D and E) Homozygous mutants that survive past 1 week have extensive degeneration in the heart, lung, and thymus. (D) In comparison with heterozygous (HET) animals, the homozygous mutants had smaller hearts, with an enlarged right atrium and enlarged superior vena cava (arrow). The size of the thymus was reduced. (E) H&E-stained hearts from heterozygous and homozygous mice revealed profound degeneration in the atrium and ventricle tissues of mutants. The atrial tissue was vacuolated (arrow), and the ventricle tissue had less density (arrowhead). AL, left atrium; AR, right atrium; V, ventricles. (G) H&E-stained lungs from P19 heterozygous and homozygous mice. Mutant lungs exhibited massive fibrosis (red arrow) and thick septae between the enlarged alveolae (red arrowhead). (H) H&E-stained mutant thymus has less cellular density and contains numerous small vacuoles.

Copyright

This image is from Zolov SN, Proc Natl Acad Sci U S A 2012 Oct 23;109(43):17472-7. Copyright 2012 National Academy of Sciences, U.S.A. J:190368

Associated Alleles

Symbol	Name
Pikfyve^Gt(AT0926)Wtsi	phosphoinositide kinase, FYVE type zinc finger containing; gene trap AT0926, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Pikfyve^Gt(AT0926)Wtsi/Pikfyve^Gt(AT0926)Wtsi	involves: 129P2/OlaHsd * C57BL/6