Phenotype Image Detail

Image

Caption

Ocular histology and neurogenesis in homozygous Vsx2 mutants. (A-H) Merged images of cryosections showing DAPI staining (blue) and melanogenic pigmentation (white) for each of the indicated genotypes and ages. Arrowheads in H point to aberrant pigmentation in peripheral retina, asterisk denotes ectopic periocular mesenchyme (POM) in vitreal cavity. (I-P) Expression patterns of the neuronal differentiation marker class III beta-Tubulin (TUBB3). Neurogenesis lagged behind wild-type and to a similar extent in the Vsx2^or-J/Vsx2^or-J (orJ) and Vsx2^tm1.1Itl/Vsx2^tm1.1Itl (R200Q) retinas, but did not initiate in the Vsx2^tm1.1Eml/Vsx2^tm1.1Eml (R227W) retina. (Q-T) Merged images of cryosections showing DAPI staining (blue) and melanogenic pigmentation (white) for each of the indicated genotypes at E17.5. The R227W retina was aberrantly pigmented, either partially (T(a)) or completely (T(b)). Arrowheads in T(a) and T(b) point to aberrant pigmentation in peripheral retina, arrows to central retinal regions, and asterisks to ectopic pigmentation in vitreal cavity. (U-W) Pigmented cells expressing VSX2^[R227W] were detected in pigmented retinal region. L, lens; RPE, retinal pigment epithelium. Scale bars: 100 um (A-T), 20 um (U-W).

Copyright

This image is from Zou C, PLoS Genet 2012 Sep;8(9):e1002924, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190452

Associated Alleles

Symbol	Name
Vsx2^or-J	visual system homeobox 2; ocular retardation Jackson
Vsx2^tm1.1Eml	visual system homeobox 2; targeted mutation 1.1, Edward M Levine
Vsx2^tm1.1Itl	visual system homeobox 2; targeted mutation 1.1, inGenious Targeting Laboratory

Associated Genotypes

Allelic Composition	Genetic Background
Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac
Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv