Phenotype Image Detail

Image

Caption

Photographs of ileocecal junctions showing reduced length and diameter of tumor alongside the cecum in Kit^tm4.1Bsm/Kit⁺ (V558delta;T669I/+) mice (Middle; red bracket indicates straight cecal GIST) in comparison with Kit^tm5.1Bsm/Kit⁺ (KitV558delta/+) mice (Bottom; blue bracket indicates twisted cecal gastrointestinal stromal tumor). Of note, the cecum is significantly shorter in Kit^tm4.1Bsm/Kit⁺ (KitV558delta;T669I/+) mice than in wild-type mice (Top; black arrow) and Kit^tm5.1Bsm/Kit⁺ (KitV558delta/+) mice. Representative pictures of 3-month-old animals are shown with colon facing down left and ileum facing down right (n >= 59 each). (Scale bar, 1 cm.)

Copyright

This image is from Bosbach B, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):E2276-83. Copyright 2012 National Academy of Sciences, U.S.A. J:188434

Associated Alleles

Symbol	Name
Kit^tm4.1Bsm	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 4.1, Peter Besmer
Kit^tm5.1Bsm	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 5.1, Peter Besmer

Associated Genotypes

Allelic Composition	Genetic Background
Kit^tm4.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N
Kit^tm5.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N