Phenotype Image Detail

Image

Caption

Cecal gastrointestinal stromal tumor (GIST) and pronounced gastric and colonic interstatial cell of Cajal (ICC) hyperplasia in Kit^tm4.1Bsm/Kit⁺ (V558delta;T669I/+) mice. Cross-sections of stomach (A-C; higher magnification is shown in A*-C*), cecum (D-F), and colon (G-I) of 3- to 4-month-old wild-type (+/+), Kit^tm5.1Bsm/Kit⁺ (V558delta/+), and Kit^tm4.1Bsm/Kit⁺ (V558delta;T669I/+) mice. Arrows indicate normal thin layer of myenteric ICC in wild-type samples. ICC hyperplasia in stomach and colon samples is indicated by black bars. Note the extensive hyperplasia involving the circular muscle layer (dotted lines) in the stomach of Kit^tm4.1Bsm/Kit⁺ mice. Photographs show representative H&E staining; n >= 3 each. (Scale bars: 50 um in A*-C*; 100 um in A-I.)

Copyright

This image is from Bosbach B, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):E2276-83. Copyright 2012 National Academy of Sciences, U.S.A. J:188434

Associated Alleles

Symbol	Name
Kit^tm4.1Bsm	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 4.1, Peter Besmer
Kit^tm5.1Bsm	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 5.1, Peter Besmer

Associated Genotypes

Allelic Composition	Genetic Background
Kit^tm4.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N
Kit^tm5.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N