Phenotype Image Detail

Image

Caption

(G) Histologic characteristics of Kit^tm4.1Bsm/Kit⁺ (V558delta;T669I/+) mice. (a and b) Toluidine blue-stained sections of dorsal skin showing increased mast cells (arrows) in mutant mice in comparison with wild-type (+/+) mice (c-h) Representative H&E stained sections of femoral bone marrow, spleen, and liver showing grossly unchanged morphology in adult mutant mice compared with wild-type mice. Note erythrocytic congestion of liver blood vessels in mutant mice (arrows in h) in comparison with wild-type mice (arrows in g). (Scale bars: 100 um in a and b; 200 um in c-h.)

Copyright

This image is from Bosbach B, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):E2276-83. Copyright 2012 National Academy of Sciences, U.S.A. J:188434

Associated Alleles

Symbol	Name
Kit^tm4.1Bsm	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 4.1, Peter Besmer

Associated Genotypes

Allelic Composition	Genetic Background
Kit^tm4.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N