Phenotype Image Detail

Image

Caption

Ptp4a2^{Gt(AQ0673)Wtsi}/Ptp4a2^{Gt(AQ0673)Wtsi} (PRL2-/-) placenta has significantly lower amount of spongiotrophoblast and glycogen cells due to reduced proliferation. A-D, histological examiniation of wild-type and mutant placentas at E12.5. A and B, PAS glycogen staining. Arrows designate islands of glycogen cells. C and D, immunohistochemistry using antibody against Ki67 to monitor proliferating cells. The blue line shows the boundary between labyrinth and spongiotrophoblast layers. De, deciduas; Sp, spongiotrophoblast; La, labyrinth. E, in situ hybridization using Ptp4a2 (PRL2) probe showing Ptp4a2 mRNA expression on frozen section of E12.5 wild-type placenta. Arrows show Ptp4a2-positive cells in the decidual layer. F, PAS glycogen staining on the section adjacent to E. Arrows show glycogen-containing cells. Note the overlap of Ptp4a2-positive cells and glycogen cells.

Copyright

This image is from Dong Y, J Biol Chem 2012 Sep 14;287(38):32172-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:190411

Associated Alleles

Symbol	Name
Ptp4a2^Gt(AQ0673)Wtsi	protein tyrosine phosphatase 4a2; gene trap AQ0673, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Ptp4a2^Gt(AQ0673)Wtsi/Ptp4a2^Gt(AQ0673)Wtsi	involves: 129P2/OlaHsd * C57BL/6
Ptp4a2^Gt(AQ0673)Wtsi/Ptp4a2^Gt(AQ0673)Wtsi Tg(CAG-Ptp4a2,-EGFP)11Zyz/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N