Phenotype Image Detail

Image

Caption

Pathological features of lipodystrophic Tg(Fabp4-SREBF1)#Dajl/0 mice with and without adipose tissue transplantation. (A) Liver, epididymal white adipose tissue (WAT) and brown adipose tissue (BAT) were assessed in wild-type (WT) or Tg(Fabp4-SREBF1)#Dajl/0 (Tg) male mice 35 days following sham surgery or adipose tissue transplantation. The BAT and WAT from mutant sham (Tg sham) mice contained a more heterogeneous population of adipocytes than seen in BAT and WAT from WT sham mice. This appearance was not affected by transplantation of WT fat into Tg mice. In contrast, the large vacuoles (fat) present in centrilobular to midzonal (c = central vein) hepatocytes of Tg sham mice were completely reversed by transplantation of WT fat into Tg mice. Livers from Tg mice receiving transplants were essentially identical to those from WT mice. An explant of WT WAT was excised from the subcutaneous area of a recipient mouse to reveal extent of adipocyte survival/immune infiltrate. Although adipocytes in the explants were heterogenous in size and structure, and in the amount of lipid contained within their single, large cytoplasmic vacuole, the explants were largely to completely viable. Individual and clusters of adipocytes were separated by cells thought to be macrophages and/or fibroblasts. Tissues from Tg sham or Tg transplanted mice treated with rmuFGF21 were indistinguishable from the appropriate vehicle-treated controls. All photographs were taken at a final magnification of 200X; H&E.

Copyright

This image is from Veniant MM, PLoS One 2012;7(7):e40164, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189510

Associated Alleles

Symbol	Name
Tg(Fabp4-SREBF1)#Dajl	transgene insertion, David J Lloyd

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Fabp4-SREBF1)#Dajl/0	involves: FVB