Phenotype Image Detail

Image

Caption

Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Mir122 LKO) mice dvelop hepatitis and fibrosis with age. (A) Portal inflammation, steatosis, and fibrosis in 6-month-old mutant mice. The inset in A depicts foci of altered hepatocytes as observed in some livers. Eight to 10 mice of each genotype were analyzed after overnight fasting. Scale bars for A: top row, 200 um; second and third rows and inset, 25 um; fourth row, 200 um.

Copyright

This image is from Hsu SH, J Clin Invest 2012 Aug 1;122(8):2871-83 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190067

Associated Alleles

Symbol	Name
Mir122^tm1.2Kgh	microRNA 122; targeted mutation 1.2, Kalpana Ghoshal

Associated Genotypes

Allelic Composition	Genetic Background
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA