Phenotype Image Detail

Image

Caption

Representative photograph of liver tumor that developed in Mir122^tm1.1Kgh/Mir122^tm1.1Kgh (germline KO) and Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Liver specific KO) mice. Left lower panel shows a representative section stained with H&E and Afp (inset). Scale bars: lower left panel, 25 um.

Copyright

This image is from Hsu SH, J Clin Invest 2012 Aug 1;122(8):2871-83 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190067

Associated Alleles

Symbol	Name
Mir122^tm1.1Kgh	microRNA 122; targeted mutation 1.1, Kalpana Ghoshal
Mir122^tm1.2Kgh	microRNA 122; targeted mutation 1.2, Kalpana Ghoshal
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Mir122^tm1.1Kgh/Mir122^tm1.1Kgh	involves: 129S1/Sv * 129X1/SvJ
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA
Mir122^tm1.1Kgh/Mir122^tm1.1Kgh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Mir122^tm1.2Kgh/Mir122^tm1.2Kgh Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA