Phenotype Image Detail

Image

Caption

Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb (KO) mice show reduced sarcoplasmic reticulum (SR) calcium leak after 6-week transverse aortic constriction (TAC). Longitudinal line scan images of spontaneous Ca2+ sparks were recorded in myocytes from both genotypes with or without TAC. Ca2+ spark frequency (CaSpF) data were averaged from isolated cardiomyocytes in wild-type (WT) sham (n = 10). WT 6-week TAC (n = 7), KO sham (n = 12), and KO 6-week TAC (n = 12) groups. ##P < 0.01 versus WT TAC. There was no significant difference between KO and WT 6-week TAC mice with respect to SR Ca2+ content, assessed by caffeine-induced Ca2+ transient amplitude (fluorescence normalized to baseline WT, 4.2 +/- 0.5; KO, 3.8 +/- 0.8).

Copyright

This image is from Ling H, J Clin Invest 2009 May;119(5):1230-40 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149675

Associated Alleles

Symbol	Name
Camk2d^tm1.1Jhb	calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Joan Heller Brown

Associated Genotypes

Allelic Composition	Genetic Background
Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb	involves: 129S4/SvJae * Black Swiss