Phenotype Image Detail

Image

Caption

Eyelids open at birth phenotype in Ppp1r13l^woe2/Ppp1r13l^woe2 mice. All mutant neonates were born with bilateral open eyelids (B) to contrast to the wild-type (WT) neonates that have closed eyelids (A). Histological analysis of P0.5 mutant mice confirmed the open eyelid phenotype and also revealed hyperkeratosis of the eyelids, stromal keratitis, absence of the conjunctival sacs, anterior synechiae, and hyperplastic corneas (D) features that were absent in the WT age matched controls (C). Further histological analysis of mutant mice at E18.5 (F) showed failure of the embryonic eyelid closure (arrows) whereas WT controls exhibited embryonic eyelid closure (E).

Copyright

This image is from Toonen J, BMC Genet 2012;13():76, an open-access article, licensee BioMed Central Ltd. J:190557

Associated Alleles

Symbol	Name
Ppp1r13l^woe2	protein phosphatase 1, regulatory subunit 13 like; waved with open eyelids 2

Associated Genotypes

Allelic Composition	Genetic Background
Ppp1r13l^woe2/Ppp1r13l^woe2	involves: 129X1/SvJ * C57BL/6