Phenotype Image Detail

Image

Caption

The Ppp1r13l^woe2/Ppp1r13l^woe2 eye phenotype at P28. Clinical evaluation of mutant eyes identified microphthalmia with corneal opacities and neovascularization (B) when compared with wild-type (WT) mice (A). In about 25% of mutant animals, unilateral or bilateral eyelid closure was noted (C). Histological analysis of mutant eyes (E) identified anterior segment abnormalities with extensive anterior synechia (arrow), corneal hypertrophy (arrowhead) and stromal vascularization. Histological analysis of closed mutant eyes (C) revealed aphakia with highly disorganized cornea, iris and retina (F). Histological analysis of adult mutant eyelids (H) identified absence of meibomian glands (arrow) whereas meibomian glands were present in age-matched WT eyelids (G) (asterisk). Scale bar in D-H = 100 um.

Copyright

This image is from Toonen J, BMC Genet 2012;13():76, an open-access article, licensee BioMed Central Ltd. J:190557

Associated Alleles

Symbol	Name
Ppp1r13l^woe2	protein phosphatase 1, regulatory subunit 13 like; waved with open eyelids 2

Associated Genotypes

Allelic Composition	Genetic Background
Ppp1r13l^woe2/Ppp1r13l^woe2	involves: 129X1/SvJ * C57BL/6