Phenotype Image Detail

Image

Caption

Scanning electron micrographs showing impaired embryonic eyelid closure in Ppp1r13l^woe2/Ppp1r13l^woe2 (woe2) embryos. At E15.5 wild-type (WT) (A, A', A") and mutant (B, B', B") embryos manifested open eyes of similar shape and with no distinct morphological difference. The accumulation of rounded peridermal cells at the leading edge of both WT (A', A") and mutant (B', B") eyelids was evident (arrowhead). Differences between the WT and mutant eyelids were evident at E16.5. The eyelids of WT embryos were completely fused (C, C', C") at the midline with flattened cells at the junction margins (C", arrow). In contrast, failure of eyelid closure was apparent in the eyes of mutant mice at this time (D, D', D"). At this time point, very few peridermal cells were evident at the eyelid margin of mutant eyelids (D" arrow).

Copyright

This image is from Toonen J, BMC Genet 2012;13():76, an open-access article, licensee BioMed Central Ltd. J:190557

Associated Alleles

Symbol	Name
Ppp1r13l^woe2	protein phosphatase 1, regulatory subunit 13 like; waved with open eyelids 2

Associated Genotypes

Allelic Composition	Genetic Background
Ppp1r13l^woe2/Ppp1r13l^woe2	involves: 129X1/SvJ * C57BL/6