Phenotype Image Detail

Image

Caption

Impaired ossification and matrix vesicle formation in Sp7^tm1.1Rnis/Sp7^tm1.1Rnis (deltaflox/deltaflox) mice. D, Von Kossa staining of tibia at E16.5 days in wild-type (WT) littermate and mutant mice. Scale bar; 100 um. Calcification of cartilage matrices is not observed. E, electron microscopy images of hypertrophic chondrocyte zone of WT and mutant mice. Right panels show higher magnification. Scale bar, 2 um. Matrix vesicles are not evident in the hypertrophic chondrocyte zone.

Copyright

This image is from Nishimura R, J Biol Chem 2012 Sep 28;287(40):33179-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:191589

Associated Alleles

Symbol	Name
Sp7^tm1.1Rnis	Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura

Associated Genotypes

Allelic Composition	Genetic Background
Sp7^tm1.1Rnis/Sp7^tm1.1Rnis	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA