Phenotype Image Detail

Image

Caption

Arrest of endochondral ossification and lack of calcification in Sp7^tm1.1Rnis/Sp7^tm1.1Rnis (deltaflox/deltaflox) mice. (A, B) Skeletal preparations stained with alcian blue and alizarin red at E15.5 days (A) and E18.5 days (B). WT, wild-type littermate. (C) Histology of cartilage of tibia at E16.5 days. Hematoxylin-eosin (HE) staining of WT and mutant. Lower panels show higher magnification. Scale bar: 100 um.

Copyright

This image is from Nishimura R, J Biol Chem 2012 Sep 28;287(40):33179-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:191589

Associated Alleles

Symbol	Name
Sp7^tm1.1Rnis	Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura

Associated Genotypes

Allelic Composition	Genetic Background
Sp7^tm1.1Rnis/Sp7^tm1.1Rnis	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA