Phenotype Image Detail

Image

Caption

Few Purkinje cells (PCs) survive in 12 week old Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 (Afg312^PC-KO) mice. Vibratome sections of the cerebellum at 12 weeks from Afg3l2^tm1Arte/Afg3l2^tm1Arte (Afg312^fl/fl) and Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 mice and stained for calbindin (A, B) to show PC loss. IBA1 (C, D) to detect resting and activated microglia, and glial fibrillary protein (GFAP) (E, F) to mark reactive astrocytes. Scale bars: 200 um (A, B), 50 um (C, D), 100 um (E, F).

Copyright

This image is from Almajan ER, J Clin Invest 2012 Nov 1;122(11):4048-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193564

Associated Alleles

Symbol	Name
Afg3l2^tm1Arte	AFG3-like AAA ATPase 2; targeted mutation 1, TaconicArtemis
Tg(Pcp2-cre)2Mpin	transgene insertion 2, Max-Planck-Institute of Neurobiology

Associated Genotypes

Allelic Composition	Genetic Background
Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6