Phenotype Image Detail

Image

Caption

Intestinal tract abnormalities in Epcam^{Gt(RST412)Byg}/Epcam^{Gt(RST412)Byg} (KO) mice. The gastrointestinal tract of wild-type (WT) (top) and KO (bottom) newborn mice was removed on day 3 after birth (left). The KO intestine appeared macroscopically smaller. No other gross abnormalities were detected. Histological analysis (hematoxylin & eosin staining) of formalin-fixed paraffin-embedded small intestine (middle) and colon (right) from day 3 mice. The KO intestinal tract shows severe villous atrophy, enterocyte necrosis, and extensive tufting (red arrowheads), both in small intestine (middle) and colon (right). Colon: high proliferation of enterocytes and reduced differentiation into goblet cells; apoptotic figures were observed (black arrowheads). Scale bars: 40 um.

Copyright

This image is from Guerra E, PLoS One 2012;7(11):e49302, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195002

Associated Alleles

Symbol	Name
Epcam^Gt(RST412)Byg	epithelial cell adhesion molecule; gene trap RST412, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Epcam^Gt(RST412)Byg/Epcam^Gt(RST412)Byg	involves: 129P2/OlaHsd * C57BL/6