Phenotype Image Detail

Image

Caption

Effects of genetic depletion of 11-cis-retinal production or absence of rod phototransduction on retinal degeneration in Rho^tm2.1Kpal/Rho^tm2.1Kpal (KK) mice. (A) Plastic sections of retinas crossing the optic nerve head of 2-month-old Rho^tm2.1Kpal/Rho^tm2.1Kpal Lrat^tm1Kpal/Lrat^tm1Kpal (KKLrat^-/-) mice. Sections were stained with toluidine blue (upper panels). Rho^tm2.1Kpal/Rho^tm2.1Kpal Lrat^tm1Kpal/Lrat^tm1Kpal retina showed increased number of rows of photoreceptor cell nuclei as compared with age-matched KK retina. This finding is consistent with the increased thickness of the outer nuclear layer (ONL) in Rho^tm2.1Kpal/Rho^tm2.1Kpal Lrat^tm1Kpal/Lrat^tm1Kpal retina shown in the corresponding spectral domain optical coherence tomography (SD-OCT) images (lower panels). (C) SD-OCT images of retinas crossing the optic nerve head from 1-month-old Rho^tm2.1Kpal/Rho^tm2.1Kpal Gnat1^tm1Clma/Gnat1^tm1Clma (KKGnat1^-/-) mice. Rho^tm2.1Kpal/Rho^tm2.1Kpal Gnat1^tm1Clma/Gnat1^tm1Clma retina displayed decreased thickness of ONL relative to an age-matched Rho^tm2.1Kpal/Rho^tm2.1Kpal (KK) retina.

Copyright

This image is from Zhang N, J Clin Invest 2013 Jan 2;123(1):121-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194158

Associated Alleles

Symbol	Name
Gnat1^tm1Clma	G protein subunit alpha transducin 1; targeted mutation 1, C L Makino
Lrat^tm1Kpal	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1, Krzysztof Palczewski
Rho^tm2.1Kpal	rhodopsin; targeted mutation 2.1, Krzysztof Palczewski

Associated Genotypes

Allelic Composition	Genetic Background
Lrat^tm1Kpal/Lrat^tm1Kpal Rho^tm2.1Kpal/Rho^tm2.1Kpal	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Gnat1^tm1Clma/Gnat1^tm1Clma Rho^tm2.1Kpal/Rho^tm2.1Kpal	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac