Phenotype Image Detail

Image

Caption

Ultrastructural analysis of optic nerve showing mitochondrial abnormalities in mt-Nd6^m3Dwa mice. Quantification of mitochondria by transmission electron microscopy (EM) (4,000X). (A) The arrow indicates an axon of 14-month-old mt-Nd6^m3Dwa mouse characterized by mitochondrial proliferation and marked thinning of the myelin sheath. (D) Abnormal mitochondrial morphology as seen with central vacuolization (arrow) and disrupted cristae (asterisks) in 14-month-old mutant.

Copyright

This image is from Lin CS, Proc Natl Acad Sci U S A 2012 Dec 4;109(49):20065-70. Copyright 2012 National Academy of Sciences, U.S.A. J:192260

Associated Alleles

Symbol	Name
mt-Nd6^m3Dwa	mitochondrially encoded NADH dehydrogenase 6; mutation 3, Douglas C Wallace

Associated Genotypes

Allelic Composition	Genetic Background
mt-Nd6^m3Dwa	B6.129S-mt-Nd6^m3Dwa