Phenotype Image Detail

Image

Caption

Temporal distribution of axonal denegation in the optic nerve in mt-Nd6^m3Dwa mice. Plastic embedded semithin sections of mouse (A and B) and human (C and D) retrobulbar optic nerves in cross-sectional profiles stained with p-phenylenedlamine for myelin. (A) Wild-type mouse at 14 months. (B) mt-Nd6^m3Dwa mouse at 14 months. Localized region of axonal swelling is oriented to the left (asterisk). (C) Human control (age, 58 years). Temporal aspect is oriented to the left (asterisk). (D) Leber hereditary optic neuropathy (LHON) patient (age, 52 years). Temporal region of axonal depletion is oriented to the left (asterisk). [Magnification: A and B, 200X (scale bars: 50 um); C and D, 25X (scale bars: 500 um).]

Copyright

This image is from Lin CS, Proc Natl Acad Sci U S A 2012 Dec 4;109(49):20065-70. Copyright 2012 National Academy of Sciences, U.S.A. J:192260

Associated Alleles

Symbol	Name
mt-Nd6^m3Dwa	mitochondrially encoded NADH dehydrogenase 6; mutation 3, Douglas C Wallace

Associated Genotypes

Allelic Composition	Genetic Background
mt-Nd6^m3Dwa	B6.129S-mt-Nd6^m3Dwa