Phenotype Image Detail

Image

Caption

Ultrastructural evidence of endoplasmic reticulum stress in the intestinal epithelium of Muc2^wnn/Muc2^wnn (Winnie) and Muc2^eey/Muc2^eey (Eeyore) mice. Semi-thin sections from resin embedded large intestine of wild-type (WT) (A),Winnie (E), and Eeyore (I) mice and small intestine of WT (M), Winnie (P), and Eeyore (S) mice stained with toluidine blue. Transmission electron micrographs from the large intestine (B-D, F-H, J-L, and V) and small intestine (N, O, Q, R, T, U, W, and X) of WT (B-D, N, and O), Winnie (F-H, Q, R, and V), and Eeyore (J-L, T, and U) mice. Note the reduced size of goblet cell thecae (indicated by a T) containing stored mucin granules and the presence of vacuoles (indicated by a V) surrounded by rough endoplasmic reticulum (RER) in Winnie and Eeyore. Other abbreviations: G, Paneth cell granule; GA, Golgi apparatus; L, lumen. Scale bars 40 um (A, E, and I), 20 um (L, O, and R), 5 um (B, F, J, and U), 2 um (C, G, K, M, P, S, and V), 1 um (W), 50 nm (D, H, L, N, Q, and T).

Copyright

This image is from Heazlewood CK, PLoS Med 2008 Mar 4;5(3):e54, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:194148

Associated Alleles

Symbol	Name
Muc2^eey	mucin 2; eeyore
Muc2^wnn	mucin 2; winnie

Associated Genotypes

Allelic Composition	Genetic Background
Muc2^wnn/Muc2^wnn	C57BL/6-Muc2^wnn
Muc2^eey/Muc2^eey	C57BL/6-Muc2^eey