Phenotype Image Detail

Image

Caption

Impaired spermatogenesis in Chtf18^tm1.1KhK/Chtf18^tm1.1KhK (-/-) mice. Seminiferous tubules stained with hematoxylin and eosin from 6-12 week old wild-type (+/+) (A) and mutant testes (B-F) are shown. Mutant tubules show a range of abnormalities. A paucity of spermatids and spermatozoa (asterisks in C) or almost complete absence of spermatogenic cells and large vacuoles (B) are seen, although a few mutant tubules demonstrate almost normal morphology (D). Disorganized testes morphology and aberrant spermatogenic cells (E and F) are also seen. Spermatogenic cells appear to be in pachynema, P, are located at the lumen, and arrows in E and F indicate aberrant cells in mutant seminiferous tubules. Scale bar is 25 um.

Copyright

This image is from Berkowitz KM, PLoS Genet 2012;8(11):e1002996, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:194119

Associated Alleles

Symbol	Name
Chtf18^tm1.1KhK	CTF18, chromosome transmission fidelity factor 18; targeted mutation 1.1, Klaus H Kaestner

Associated Genotypes

Allelic Composition	Genetic Background
Chtf18^tm1.1KhK/Chtf18^tm1.1KhK	Not Specified